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. 2019 Apr 4;10:615. doi: 10.3389/fimmu.2019.00615

Figure 5.

Figure 5

Inhibition of Ply-mediated necroptosis decreases the rate of Spn clearance. Number of Spn in nasal homogenates of (A) wildtype and MLKL KO mice colonized with TIGR4 and (B) wildtype mice colonized with TIGR4 or TIGR4Δply collected at days 0, 7, 14, and 21 post-inoculation. Mean ± SEM shown. n = 5 – 10 mice/group; two-way ANOVA with Sidak multiple comparisons, * = P < 0.05. Dashed line indicates limit of detection. Note that day 14 and 21 homogenates also plated in 100 μL spread plates to confirm clearance (limit of detection 100 CFU/g tissue).