Summary of findings for the main comparison. Sublingual glucose compared to oral (swallowed) glucose for treatment of hypoglycaemia.
| Sublingual glucose compared to oral (swallowed) glucose for treatment of hypoglycaemia | ||||||
| Patient or population: children with hypoglycaemia associated with moderate clinical symptoms of acute malaria or moderate respiratory tract infections Setting: first‐aid setting, pre‐hospital setting (Hamdallaye Health Center) Intervention: sublingual glucose Comparison: oral (swallowed) glucose | ||||||
| Outcomes | Risk with oral (swallowed) glucose | Risk with sublingual glucose | Relative effect (95% CI) | № of participants (studies) | Certainty of the evidence (GRADE) | Comments |
| Resolution of symptoms, time to resolution of symptoms | Not reported | |||||
| Blood/plasma glucose concentrations at 20 minutes | The mean blood/plasma glucose concentrations at 20 minutes was 76 mg/dL | The MD was 17 mg/dL higher (4.4 mg/dL higher to 29.6 mg/dL higher) | ‐ | 42 (1) | ⊕⊝⊝⊝ very low | |
|
Resolution of hypoglycaemia Definition: (a) within 20 minutes (b) within 80 minutes |
(a) 467 per 1000 (b) 733 per 1000 |
(a) 205 per 1000 (44 to 983) (b) 14 per 1000 (0 to 252) |
(a) RR 1.26
(0.91 to 1.74) (b)RR 2.10 (1.24 to 3.54) |
(a)/(b) 42 (1) | (a)/(b)
⊕⊝⊝⊝ very low |
|
| Time to resolution of hypoglycaemia | The mean time to resolution of hypoglycaemia was 80 minutes | The MD was 51.5 min lower (58 minutes lower to 45 min lower) | ‐ | 42 (1) | ⊕⊝⊝⊝ very low | |
|
Adverse events Follow‐up: 80 minutes |
See comment | 42 (1) | ⊕⊝⊝⊝ very low | No adverse events were reported in either group. | ||
| Treatment delay | Not reported | |||||
| CI: confidence interval; MD: mean difference; RR: risk ratio | ||||||
| GRADE Working Group grades of evidence High certainty: We are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
All outcomes downgraded by one level because of risk of bias and indirectness, and by two levels because of serious imprecision ‐ see Appendix 14.