Item	Study ID
Study author	Chlup 2009
Brief name	Buccal vs oral administration
Recipient	Healthy volunteers
Why	To assess the efficacy of different commercially available glucose products on the evolution of plasma glucose concentration
What (materials)	I: glucose spray, manufacturer not mentioned C: dextrose tablet (6 g)
What (procedures)	The glucose product (intervention or comparator) was administered after an average fasting time of 8 to 9 hours (range was 6 to 13 hours). Plasma glucose concentration was measured, and the glucose product was administered immediately after the first measurement. Each intervention was administered 3 times (on separate days, following fasting)
Who provided	Researcher, no further information available
How (mode of delivery; individual or group)	I: spray doses applied on the mucosa of the cheek, without swallowing C: chewing and consumption of the tablet
Where	Experimental setting
When and how much	I: 10 glucose spray doses (5 doses per cheek); one single administration C: one dextrose tablet (6 g); one single administration
Tailoring	NA
Modification of intervention throughout the study	NA
Strategies to improve or maintain intervention fidelity	NA
Extent of intervention fidelity	NA
Study author	Barennes 2005
Brief name	Sublingual vs oral administration
Recipient	Children 1‐15 years with moderate symptoms of malaria or respiratory tract infections and low blood glucose concentrations
Why	To compare different forms of glucose administration to relieve hypoglycaemia
What (materials)	I: wet sugar C: sugar
What (procedures)	Glucose was given in the morning, after fasting overnight (starting after dinner)
Who provided	Physician
How (mode of delivery; individual or group)	I: wet sugar was applied under the tongue without swallowing C: sugar on the tongue, swallowed
Where	Hamdallaye Health Center
When and how much	2.5 g of sugar (intervention or comparator) was administered in intervention and comparator group
Tailoring	NA
Modification of intervention throughout the study	NA
Strategies to improve or maintain intervention fidelity	NA
Extent of intervention fidelity	NA
Study author	Slama 1990
Brief name	Dextrose gel vs oral administration
Recipient	Participants with insulin‐dependent diabetes
Why	To evaluate the efficacy of different forms of sugar in correcting the hypoglycaemic reactions of insulin‐treated diabetic patients
What (materials)	I: 15 g of glucose in the form of 40 g of a 40% dextrose gel (Hypostop, Novo Industries) C1: glucose tablet (15 g) (Glucose Tablets, Becton Dickinson) C2: a solution of 15 g of glucose in 150 mL of water C1 and C2 were combined as one "oral group" in the data analyses
What (procedures)	See above
Who provided	Not reported, but probably a physician (hospital setting)
How (mode of delivery; individual or group)	I: not described how the gel was applied, but should be applied to the cheek according to the manufacturer C1: swallowed without water C2: swallowed
Where	Hospital
When and how much	I: 15 g C1: 1 tablet (15 g) C2: 15 g of glucose in 150 mL water
Tailoring	NA
Modification of intervention throughout the study	NA
Strategies to improve or maintain intervention fidelity	NA
Extent of intervention fidelity	NA
Study author	Gunning 1978
Brief name	Buccal vs oral administration
Recipient	Healthy volunteers
Why	To evaluate the efficacy of instant glucose by studying the absorption of this preparation in normal volunteers
What (materials)	Instant glucose containing 50 µCi of 2‐tritiated glucose
What (procedures)	At 8 AM after an overnight fast, an indwelling intravenous cannula was inserted into an antecubital vein. After a 30‐minute rest period, two initial blood samples were obtained, following which 15 g of instant glucose was administered. Blood samples were analysed for glucose using fluorometric enzymatic techniques
Who provided	Researcher, no further information available
How (mode of delivery; individual or group)	I: glucose was placed between the teeth and cheek of each subject. Participants were encouraged not to swallow C: glucose was swallowed
Where	Experimental setting
When and how much	15 g of labelled instant glucose was administered in intervention and comparator group
Tailoring	NA
Modification of intervention throughout the study	NA
Strategies to improve or maintain intervention fidelity	NA
Extent of intervention fidelity	NA
—: denotes not reported C: comparator; g: gram; I: intervention; NA: not applicable; µCi: micro Curie; mL: millilitre