Items		(1) Resolution of symptoms	(2) Time to resolution of symptoms	(3) Blood or plasma glucose concentration at 20 minutes	(4) Resolution of hypoglycaemia	(5) Time to resolution of hypoglycaemia	(6) Adverse events	(7)Treatment delay
Trial limitations (risk of bias)a	Was random sequence generation used (i.e. no potential for selection bias)?	Unclear	NA	Unclear	NA	NA	NA	NA
	Was allocation concealment used (i.e. no potential for selection bias)?	Unclear		Unclear
	Was there blinding of participants and personnel (i.e. no potential for performance bias) or outcome not likely to be influenced by lack of blinding?	No (↓)		Yes
	Was there blinding of outcome assessment (i.e. no potential for detection bias) or was outcome measurement not likely to be influenced by lack of blinding?	No (↓)		Yes
	Was an objective outcome used?	No (↓)		Yes
	Were more than 80% of participants enrolled in trials included in the analysis (i.e. no potential reporting bias)?e	Yes		Yes
	Were data reported consistently for the outcome of interest (i.e. no potential selective reporting)?	Yes		Yes
	No other biases reported (i.e. no potential of other bias)?	Yes		Yes
	Did the trials end up as scheduled (i.e. not stopped early)?	Yes		Yes
Indirectness	Were the populations in included studies applicable to the decision context?	Applicable		Applicable
	Were the interventions in the included studies applicable to the decision context?	Highly applicable		Highly applicable
	Was the included outcome not a surrogate outcome?	Yes		Yes
	Was the outcome timeframe sufficient?	Sufficient		Sufficient
	Were the conclusions based on direct comparisons?	Yes		Yes
Imprecisionc	What is the magnitude of the median sample size (high: 300 participants, intermediate: 100‐300 participants, low: < 100 participants)?e	Low (↓)		Low (↓)
	What was the magnitude of the number of included studies (large: > 10 studies, moderate: 5‐10 studies, small: < 5 studies)?e	Small (↓)		Small (↓)
	Was the outcome a common event (e.g. occurs more than 1/100)?	Yes		Not applicable
Publication biasd	Was a comprehensive search conducted?	Yes		Yes
	Was grey literature searched?	Yes		Yes
	Were no restrictions applied to study selection on the basis of language?	Yes		Yes
	There was no industry influence on studies included in the review?	Yes		Yes
aQuestions on risk of bias are answered in relation to the majority of the aggregated evidence in the meta‐analysis rather than to individual trials. bQuestions on inconsistency are primarily based on visual assessment of forest plots and the statistical quantification of heterogeneity based on I². cWhen judging the width of the confidence interval it is recommended to use a clinical decision threshold to assess whether the imprecision is clinically meaningful. dQuestions address comprehensiveness of the search strategy, industry influence, funnel plot asymmetry and discrepancies between published and unpublished trials. eDepends on the context of the systematic review area. (↓): key item for potential downgrading the certainty of the evidence (GRADE) as shown in the footnotes of the 'Summary of finding' table(s); NA: not applicable