Chlup 2009.

Methods	Study design: non‐randomised controlled trial (cross‐over study)
Participants	Inclusion criteria: no specific inclusion criteria mentioned Exclusion criteria: no specific exclusion criteria mentioned Diagnostic criteria: being healthy Setting: experimental setting in healthy volunteers Age group: 16 healthy adults (mean (± SE), age 21.8 ± 0.78 years Gender distribution: 2 females and 14 males Country where study was performed: Czech Republic
Interventions	Intervention: buccal treatment: 10 glucose spray doses (five doses on the mucosa of each cheek, without swallowing) Comparators: oral treatments: one sachet of liquid sugars (5.2 g glucose, 5.2 g sucrose, 5.2 g fructose) dextrose tablet to be chewed (only these data fulfilled selection criteria and were extracted) Duration of intervention: 3 sequential sets of 4 sessions. In each set there was one control session and 3 sessions testing different products of dextrose and other sugars Duration of follow‐up: 30 minutes Run‐in period: the study started after an average fasting time of 8 to 9 hours (range 6 to 13 hours) Number of study centres: —
Outcomes	Reported outcome(s) in full text of publication: blood or plasma glucose concentration at 20 minutes (mg/dL) (plasma glucose concentration)
Study registration	NA
Publication details	Language of publication: English Funding: non‐commercial funding (supported by the grants IGA NR 7825‐3, IGA 10823, Ministry of Health, and MSM 6198959216, Ministry of Education, Czech Republic) Publication status: peer‐reviewed journal
Stated aim for study	Quote from publication: "The purpose of this prospective controlled trial was to assess the efficacy of three commercially available glucose products (1) buccal glucose spray, (2) liquid sugars, and (3) dextrose tablet on the evolution of plasma glucose concentration."
Notes	Risk of bias assessed with ROBINS‐I tool for non‐randomised studies (see Appendix 4)