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. Author manuscript; available in PMC: 2019 Apr 11.
Published in final edited form as: Psychopharmacology (Berl). 2018 Nov 28;236(1):517–529. doi: 10.1007/s00213-018-5122-2

Figure 3. Effects of post-session RGFP966 on extinction and reinstatement.

Figure 3.

(A) Average active and inactive lever presses during the first two extinction sessions (shown in 15-min time blocks). Two groups received a 30-min session duration in Extinction Session 1 followed by either injection of RGFP966 (n=7) or Vehicle (n=8). A third group received a 2-hr extinction session followed by Vehicle (n=8). All groups received a 2-hr extinction session the next day (Ext 2). Extinction across 2-hr sessions are shown for (B) Sessions 1–12 and (C) Sessions 13–23, which occurred between reinstatement sessions. (D) Responding during the first 12 extinction. (C) Responding during each extinction session prior to reinstatement and during reinstatement testing in a novel context (CTX), with the cue previously associated with cocaine (CUE), and following a priming injection of cocaine (COC). Error bars indicate the standard error of the mean (±SEM). * p<0.05 (see text for statistical details).