Table 5.
Comparisons of retinal layer thicknesses (microns) between probable tauopathy subgroup patients and normal controls at follow-up visit.
| Unadjusted analysis |
Adjusted analysisc |
|||||
|---|---|---|---|---|---|---|
| Retinal layera | Controls (N = 30, 47 eyes) Mean (SE) | Probable tauopathy patients (N = 9, 16 eyes) Mean (SE) | p-valueb | Controls (N = 30, 47 eyes) Mean (SE) | Probable tauopathy patients (N = 9, 16 eyes) Mean (SE) | p-valueb |
| Total retina | 304 (2.3) | 292 (2.9) | 0.04 | 305 (2.9) | 291 (4.9) | 0.07 |
| Outer retina | 142 (1.4) | 130 (3.2) | 0.03 | 143 (1.6) | 128 (4.4) | 0.03 |
| RNFL | 23.5 (0.4) | 23.5 (0.9) | 0.96 | 23.5 (0.5) | 23.4 (1.3) | 0.92 |
| GCL | 39.6 (1.1) | 37.7 (1.1) | 0.33 | 38.9 (1.4) | 39.7 (2.1) | 0.79 |
| IPL | 38.9 (0.9) | 37.5 (1.4) | 0.49 | 39.1 (1.1) | 36.9 (1.9) | 0.40 |
| INL | 35.7 (0.5) | 34.0 (0.7) | 0.14 | 35.8 (0.6) | 33.8 (0.8) | 0.11 |
| OPL | 24.5 (0.6) | 29.5 (1.9) | 0.07 | 24.9 (0.8) | 28.4 (2.2) | 0.19 |
| ONL | 96.1 (1.2) | 89.1 (2.5) | 0.11 | 97.6 (1.4) | 85.2 (3.7) | 0.02 |
| EZ | 15.1 (0.1) | 14.0 (0.1) | 0.002 | 15.0 (0.2) | 14.3 (0.2) | 0.02 |
| POS | 11.8 (0.4) | 10.1 (0.5) | 0.09 | 11.6 (0.6) | 10.7 (1.0) | 0.49 |
| IZ | 18.9 (0.5) | 17.0 (0.7) | 0.13 | 18.4 (0.6) | 18.2 (1.1) | 0.86 |
| RPE | 18.2 (0.5) | 20.1 (0.8) | 0.17 | 18.5 (0.6) | 19.1 (1.1) | 0.67 |
SE, standard error; RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; EZ, ellipsoid zone; POS, photoreceptor outer segments; IZ, interdigitation zone; RPE, retinal pigment epithelium. aSpectral domain optical coherence tomography (SD-OCT) parameters (in microns) are the average of five central subfields (central and 4 parafoveal subfields) of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid centered at the foveola. Total retina: distance from RNFL to IZ; Outer Retina: distance from ONL to IZ. bInter-eye correlation of SD-OCT measurements was accounted for using generalized estimating equations (GEE); significant values (p < 0.05) in bold letters. cAdjusted for age, sex, and race.