Table 7.
Comparisons of rate (microns per year) of retinal layer thickness change between probable tauopathy subgroup patients and controls.
| Unadjusted analysis |
Adjusted analysisc |
|||||
|---|---|---|---|---|---|---|
| Retinal layera | Controls (N = 30, 47 eyes) Mean (SE) | Patients (N = 9, 16 eyes) Mean (SE) | p-valueb | Controls (N = 30, 47 eyes) Mean (SE) | Patients (N = 9, 16 eyes) Mean (SE) | p-valueb |
| Total retina | 0.5 (0.6) | −0.8 (0.7) | 0.29 | 0.8 (0.7) | −1.8 (1.0) | 0.09 |
| Outer retina | 0.1 (0.7) | −3.2 (1.2) | 0.04 | 0.4 (0.7) | −3.9 (1.3) | 0.03 |
| RNFL | 0.3 (0.3) | 0.8 (0.4) | 0.32 | 0.3 (0.4) | 0.8 (0.6) | 0.52 |
| GCL | −1.0 (0.5) | 0.8 (1.1) | 0.24 | −1.2 (0.7) | 1.4 (1.8) | 0.24 |
| IPL | 1.1 (0.5) | −1.4 (1.0) | 0.08 | 1.5 (0.7) | −2.5 (1.6) | 0.06 |
| INL | 0.0 (0.2) | −0.5 (0.3) | 0.11 | 0.2 (0.2) | −0.9 (0.3) | 0.02 |
| OPL | −0.2 (0.4) | 2.7 (0.8) | 0.02 | −0.3 (0.4) | 3.3 (0.9) | 0.008 |
| ONL | −0.1 (0.4) | −2.2 (0.8) | 0.08 | 0.1 (0.5) | −2.9 (1.1) | 0.04 |
| EZ | −0.1 (0.1) | −0.4 (0.1) | 0.09 | −0.1 (0.1) | −0.4 (0.2) | 0.22 |
| POS | 0.1 (0.1) | 0.1 (0.3) | 0.90 | 0.1 (0.2) | 0.0 (0.3) | 0.84 |
| IZ | 0.2 (0.3) | −0.6 (0.4) | 0.11 | 0.2 (0.3) | −0.7 (0.5) | 0.14 |
| RPE | −0.1 (0.3) | 0.9 (0.6) | 0.12 | −0.2 (0.3) | 1.0 (0.7) | 0.14 |
SE, standard error; RNFL, retinal nerve fiber layer; GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; EZ, ellipsoid zone; POS, photoreceptor outer segments; IZ, interdigitation zone; RPE, retinal pigment epithelium. aSpectral domain optical coherence tomography (SD-OCT) parameters (in microns) are the average of five central subfields (central and 4 parafoveal subfields) of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid centered at the foveola. Total retina: distance from RNFL to IZ; Outer Retina: distance from ONL to IZ. bInter-eye correlation of SD-OCT measurements was accounted for using generalized estimating equations (GEE); significant values (p < 0.05) in bold letters. cAdjusted for age, sex, and race.