Table 8.
Spearman correlation between retinal layers and Mini-Mental State Examination for all FTD patients and probable tauopathy subgroup.
| Baseline SD-OCT with change of MMSE |
Follow-up SD-OCT with follow-up MMSE |
Change of SD-OCT with follow-up MMSE |
Change of SD-OCT with change of MMSE |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Retinal layer thicknessa | rhob | p-valuec | rhod | p-valuec | rhod | p-valuec | rhod | p-valuec | Patient group |
| Outer retina | −0.12 | 0.65 | 0.56 | 0.03 | 0.79 | <0.001 | 0.60 | 0.02 | FTD patients |
| Outer nuclear layer | 0.02 | 0.93 | 0.54 | 0.04 | 0.69 | 0.005 | 0.46 | 0.09 | |
| EZ | 0.14 | 0.60 | 0.19 | 0.49 | 0.13 | 0.65 | 0.19 | 0.49 | |
| Outer retina | 0.43 | 0.25 | 0.56 | 0.15 | 0.75 | 0.03 | 0.73 | 0.04 | Probable tauopathy subgroup |
| Outer nuclear layer | 0.49 | 0.18 | 0.51 | 0.19 | 0.51 | 0.19 | 0.55 | 0.16 | |
| EZ | 0.38 | 0.31 | 0.08 | 0.84 | −0.14 | 0.73 | −0.04 | 0.93 | |
Significant values (p < 0.05) in bold letters. SD-OCT, spectral domain optical coherence tomography; MMSE, mini-mental state examination; EZ, ellipsoid zone; FTD, frontotemporal degeneration. aCorrelation was determined with the average of the 5 central subfields of the Early Treatment Diabetic Retinopathy Study grid. bFor FTD patients: N = 16; median number of months between baseline and follow-up MMSE = 17 (interquartile range, 12–24 months); median baseline MMSE = 28 (interquartile range, 26–29); median follow-up MMSE = 26 (interquartile range, 23–28). For probable tauopathy subgroup: N = 9; median number of months between baseline and follow-up MMSE = 15 (interquartile range, 12–27 months); median baseline MMSE = 26 (interquartile range, 24–29); median follow-up MMSE = 25 (interquartile range, 20–28). cFor subjects with 2 study eyes, the average of the 2 eyes was correlated. dFor FTD patients: N = 15; median number of months between baseline and follow-up MMSE = 17 (interquartile range, 12–25 months); median baseline MMSE = 28 (interquartile range, 26–29); median follow-up MMSE = 26 (interquartile range, 24–28). For probable tauopathy subgroup: N = 8; median number of months between baseline and follow-up MMSE = 19 (interquartile range, 13–27 months); median baseline MMSE = 27 (interquartile range, 24–29); median follow-up MMSE = 26 (interquartile range, 22–28).