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RDX8940 induces dose-dependent increases in total glucagon-like peptide-1 (tGLP-1) and tGLP-2 secretion in mice fed a standard diet (A), which is enhanced by repeated dosing (B). Bars show mean values; error bars show standard error of the mean (n = 8 per group). tGLP-1 and tGLP-2 levels were measured 8 h after the last dose. The single-dose data presented in B are the same as those shown in A. ***P < 0.001 and ****P < 0.0001 vs. vehicle. b.i.d., twice daily.
