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RDX8940 does not inhibit gallbladder emptying. Bars show mean values; error bars show standard error of the mean (n = 6 per group). Images from mice fed egg yolk show inhibition of gallbladder emptying (see arrows) following dosing with systemic TGR5 agonist INT-777 at 30 mg/kg, but not with RDX8940 30 mg/kg or 100 mg/kg. *P < 0.05 and **P < 0.01 vs. saline.
