Table 1.
Comparisons of BW, BT, and resting ventilatory changes in control and HK483 mice over the infection period
| Days Postinfection | ||||
|---|---|---|---|---|
| Variable (Group) | 0 | 2 | 4 | 6 |
| BW, Δ% | ||||
| Control | 0.0 ± 0.0 | −0.8 ± 0.7 | 0.2 ± 1.2 | −1.9 ± 0.7 |
| HK483 | 0.0 ± 0.0 | −3.7 ± 1.6 | −13.8 ± 1.5*†# | −23.6 ± 1.8*†# |
| BT, °C | ||||
| Control | 37.2 ± 0.1 | 36.8 ± 0.1 | 37.1 ± 0.2 | 37.0 ± 0.2 |
| HK483 | 37.5 ± 0.1 | 37.0 ± 0.1 | 36.1 ± 0.3*†# | 31.1 ± 1.1*†# |
| V̇e, ml/min | ||||
| Control | 44.7 ± 2.5 | 43.8 ± 2.2 | 46.0 ± 2.1 | 44.7 ± 2.1 |
| HK483 | 45.5 ± 3.3 | 53.0 ± 4.2*# | 62.5 ± 5.5*†# | 49.3 ± 4.9# |
| fR, breaths/min | ||||
| Control | 245.9 ± 4.5 | 247.1 ± 4.3 | 249.8 ± 6.0 | 250.2 ± 7.4 |
| HK483 | 243.3 ± 6.1 | 279.7 ± 6.8*†# | 287.8 ± 6.9*† | 256.8 ± 9.9# |
| VT, ml | ||||
| Control | 0.18 ± 0.01 | 0.18 ± 0.00 | 0.18 ± 0.00 | 0.18 ± 0.00 |
| HK483 | 0.19 ± 0.00 | 0.20 ± 0.01 | 0.22 ± 0.01*†# | 0.20 ± 0.01# |
Values are means ± SE; n = 7, 7, 8, and 10 on 0, 2, 4, and 6 dpi for both control and HK483 groups, which are the same for Fig. 1 and Table 2. BT, body temperature; BW, body weight; dpi, days postinfection; fR, respiratory frequency; V̇e, minute ventilation; VT, tidal volume.
*
P < 0.01 compared with 0 dpi;
†
P < 0.01 vs. control on the given day;
#
P < 0.05 compared with the previous day in HK483 mice.