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. 2018 Dec 21;316(3):E443–E452. doi: 10.1152/ajpendo.00360.2018

Fig. 6.

Fig. 6.

Altered expression of cell cycle proteins in the retina of Akita mice and RPE cells treated with miR-451a. A–D: Western blots of ATF2, CyclinA1, CyclinD1 and MMP2 in the retina of Akita mice compared with age-matched wild-type (WT) mouse; GAPDH was used as loading control. E: quantification of the Western blots (A–D) normalized by WT (mean ± SE, n = 3, *P < 0.05). F: the mRNA levels of ATF2, CyclinA1, CyclinD1, and MMP2 in the retina of Akita mice were measured by qRT-PCR compared with WT control (mean ± SE, n = 3, *P < 0.05). G: ARPE-19 cells were transfected with miR-451a mimic (M-451a) and mimic-control (M-C) for 48 h, and protein levels of CyclinA1, CyclinD1, MMP-2, and GAPDH were measured by Western blot analysis. H: CyclinA1, CyclinD1, and MMP-2 protein levels were quantified by densitometry (mean ± SE; n = 3, ***P < 0.001).