Table 1.

Metabolites altered in the newborn cardiac tissue due to chronic maternal cortisol exposure in late gestation

		Relative Means ± SE
Metabolite	P Value	Control	Cortisol	Log2(FC) (Cortisol/Control)
Dimethylamine	1.20E−04	0.305 ± 0.018	0.196 ± 0.009	−0.64
Valine	3.11E−04	0.078 ± 0.005	0.189 ± 0.022	1.27
GPC	6.48E−03	11.356 ± 0.333	9.014 ± 0.569	−0.33
Glutamine	0.01	1.847 ± 0.097	2.331 ± 0.114	0.34
Succinate	0.01	0.234 ± 0.016	0.340 ± 0.028	0.54
Betaine	0.03	2.600 ± 0.130	2.085 ± 0.138	−0.32
Glutamate	0.05	2.915 ± 0.115	2.445 ± 0.145	−0.25
Scyllo-inositol	0.06	0.732 ± 0.039	0.851 ± 0.033	0.22
Taurine	0.07	9.844 ± 0.646	7.945 ± 0.496	−0.31
Lactate	0.22	5.931 ± 0.236	6.612 ± 0.375	0.16
Ethanolamine	0.28	0.645 ± 0.018	0.615 ± 0.013	−0.07
Isoleucine	0.32	0.352 ± 0.032	0.423 ± 0.047	0.26
Alanine	0.35	2.491 ± 0.131	2.792 ± 0.220	0.16
1,2-Propanediol	0.44	4.104 ± 0.463	3.511 ± 0.418	−0.23
AMP	0.59	0.238 ± 0.016	0.254 ± 0.018	0.10
2-Hydroxybutyrate	0.60	0.469 ± 0.058	0.526 ± 0.067	0.16
Myo-inositol	0.61	8.404 ± 0.443	8.755 ± 0.331	0.06
Lipid (-CH = CH-)	0.64	5.072 ± 0.616	5.581 ± 0.634	0.14
Lipid (β-CH2)	0.69	4.936 ± 0.657	5.371 ± 0.608	0.12
Inosine	0.81	0.497 ± 0.033	0.485 ± 0.023	−0.03
Lipid (α-CH2)	0.84	5.023 ± 0.719	5.276 ± 0.739	0.07
Creatine	0.85	13.463 ± 0.291	13.360 ± 0.317	−0.01
Ethanol	0.87	1.004 ± 0.115	1.041 ± 0.136	0.05
Choline	0.88	2.072 ± 0.129	2.043 ± 0.089	−0.02
Glutathione	0.91	0.547 ± 0.022	0.543 ± 0.014	−0.01
Lipid (CO2-CH)	0.93	1.051 ± 0.091	1.064 ± 0.081	0.02
Lipid (-CH3)	0.95	19.128 ± 1.352	19.273 ± 1.488	0.01

For control and cortisol groups, n = 18 from 6 animals. GPC, glycerophosphocholine; AMP: adenosine 5′-monophosphate; GPC, glycerophosphocholine; FC, fold change.