Table 4.

Significant metabolites in maternal serum due to chronic maternal cortisol exposure in late gestation

Metabolite	Intercept	SE	P Value	Trend
All time points (n = 42 control from 9 animals, n = 16 cortisol from 4 animals)
Betaine	−1.95	0.69	0.01	Control > Cort
Scyllo-inositol	0.35	0.10	1.28E−03	Cort > control
1-Methylhistidine	−0.07	0.02	1.20E−03	Control > Cort

	Relative Means ± SE
	Control	Cortisol	P Value	Log2(FC) (Cortisol/Control)
0–2 Days until delivery (n = 9 control, n = 3 cortisol)
1-Methylhistidine	0.172 ± 0.007	0.079 ± 0.004	2.68E−03	−1.13
Betaine	9.880 ± 0.311	6.670 ± 0.174	0.01	−0.57
3–6 Days until delivery (n = 9 control, n = 4 cortisol)
Betaine	9.791 ± 0.238	6.647 ± 0.117	8.78E−04	−0.56
Anserine	0.291 ± 0.011	0.398 ± 0.008	9.53E−03	0.45
1-Methylhistidine	0.173 ± 0.010	0.081 ± 0.007	0.01	−1.11
Scyllo-inositol	0.216 ± 0.030	0.804 ± 0.106	0.01	1.90
7–10 Days until delivery (n = 8 control, n = 4 cortisol)
Lactate	6.432 ± 0.220	11.754 ± 1.060	0.03	0.87
3-Hydroxyisobutyrate	0.110 ± 0.005	0.165 ± 0.010	0.04	0.59
1-Methylhistidine	0.149 ± 0.009	0.093 ± 0.003	0.05	−0.68

FC, fold change.