Fig. 3.
Vasodilatation (A) and vascular superoxide (O2·−) production (B) in aortas isolated from mice treated with a combination of cigarette smoke and angiotensin II (ANG II; 0.2 mg⋅kg−1⋅day−1) for 2 wk. Vascular O2·− was measured by the 1-hydroxy-4-methoxy-2,2,6,6-tetramethylpiperidine hydrochloride spin probe and electron spin resonance, as we have previously described (11). Results are means ± SD; n = 6. *P < 0.01 vs. wild-type (WT) mice; **P < 0.05 vs. WT + ANG II/smoke. mCAT, mice expressing mitochondria-targeted catalase.