Fig. 1.
Cannabinoid receptor 2 (CB2) agonist SMM-295 promotes increased renal cortical perfusion. A: chemical structure of Δ9-THC and SMM-295. Measurement of renal cortical perfusion by laser Doppler flowmetry (B) and mean arterial pressure (MAP, C) following intravenous infusion of vehicle (Veh; n = 10) or SMM-295 (6 mg/kg; n = 7) in anesthetized C57BL/6J mice, and SMM-295 (6 mg/kg; n = 6) in Cnr2 knockout (KO) mice. Data are graphed as a percent change from baseline levels in each mouse. *P < 0.0001 significant difference in cortical perfusion for both groups (B, C) and only vehicle group for MAP (C); **P < 0.05 significant difference between wild-type (WT) and Cnr2 KO mouse.