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. 2019 Feb 1;51(3):90–96. doi: 10.1152/physiolgenomics.00001.2019

Fig. 5.

Fig. 5.

SMM-295 increases luminal diameter of preconstricted isolated perfused afferent arterioles. Afferent arterioles were isolated from C57BL/6 mice and perfused to measure luminal diameter changes at baseline and after treatment with norepinephrine (NE; 1 µM) and SMM-295 (5 µM). Representative images of the isolated afferent arterioles at baseline (control) (A) and with NE (B), and NE + SMM-295 (C) treatment. Graphical analyses of the luminal diameter changes, if any, during the following conditions: SMM-295 incubation during 2 consecutive periods (15 min each period) (D); NE incubation during 2 consecutive periods (15 min each period) (E); NE incubation during the first period, and NE + SMM-295 during the second period (F). n = 4 arterioles per group. *P = 0.0019 significant difference between NE treatment with or without vehicle; **P < 0.001 significant difference between NE alone and NE + SMM-295 groups. Black arrows indicate where the luminal diameter was measured.