Table 3. Multivariate Cox proportional hazards model of predictive factors in OS and DFS.
| Covariate | OS | DFS | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||
| ≤60 | Reference | Reference | ||
| >60 | 1.982 (1.133~3.645) | 0.021 | 1.344 (0.860~2.565) | 0.385 |
| Gender | ||||
| Female | Reference | Reference | ||
| Male | 1.324 (0.654~2.325) | 0.067 | 1.930 (0.922~3.856) | 0.194 |
| Stage | ||||
| I~II | Reference | Reference | ||
| III~IV | 1.765 (0.845~3.944) | 0.188 | 1.655 (0.695~3.899) | 0.305 |
| EBV infection | ||||
| (-) | Reference | Reference | ||
| (+) | 1.134 (0.675~2.254) | 0.655 | 1.358 (0.728~2.513) | 0.286 |
| Src-1 | ||||
| Low | Reference | Reference | ||
| High | 1.645 (1.023~2.679) | 0.048 | 1.574 (1.013~2.286) | 0.065 |
| Twist1 | ||||
| Low | Reference | Reference | ||
| High | 1.721 (1.179~3.334) | 0.021 | 1.539 (1.095~3.084) | 0.017 |
| Lymph node metastasis | ||||
| NO | Reference | Reference | ||
| Yes | 1.011 (0.089~1.532) | 0.435 | 1.232 (0.579~2.084) | 0.501 |
| Distant metastasis | ||||
| NO | Reference | Reference | ||
| Yes | 1.754 (1.106~2.913) | 0.012 | 1.622 (1.064~2.563) | 0.014 |
OS: Overall Survival; PFS, Progression-free Survival.