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. 2019 Apr 11;14(4):e0215208. doi: 10.1371/journal.pone.0215208

Fig 2. SIRT1 protection is blocked by inhibition of HDACs.

Fig 2

A. GFP or SIRT1-Flag were ectopically expressed in CGNs for 24 h. Media was then switch to that containing either HK, LK, or LK supplemented with the following inhibitors: PD98059 (MEK inhibitor), U0126 (MEK inhibitor), LY294002 (PI3-K inhibitor), Wortmannin (PI3-K inhibitor), IC261 (CK1 inhibitor), H89 (PKA inhibitor), KN-62 (CaMKII inhibitor) (***p<0.001; n = 3). B. CGNs were transfected and treated as described in (A) as indicated with the following inhibitors: trichostatin A (TSA), pimelic diphenylamide 106 (PIM), or RGFP966 (*p<0.05, **p<0.01, ***p<0.001; n = 3).