Fig 6. Loss of the Δ8 region is toxic to neurons.

A. Expression of Δ8 induced death in otherwise healthy neurons. GFP or Δ8 were expressed into CGNs and then treated with HK media for 24 h (*p<0.05; n = 3). B. CGNs were transfected with GFP or Δ8. Neurons were then treated with either HK, LK, or LK media supplemented with the following for 24 h: DMSO, SP600125 (JNK inhibitor), Roscovitine (CDK inhibitor), SB216763 (GSK3 inhibitor), HSB-13 (***p<0.001; n = 3).