Table 1. Details of the per-tissue computations performed in the ensemble footprinting phase.

Data sizes are in GB. Times are in hours on a 32-core AWS node; they sum to 2,149.1 node hours or 68,771 core hours. DNase: DNase Hypersensitivity (DNase-seq) data from ENCODE. Align: Aligned sequence data. Foot: Footprint data and footprint inference computation. Numbers may not sum perfectly due to rounding.

Tissue	Biosamples	Replicates	Data size			Compute time
			DNase	Align	Foot	Align	Foot
adrenal gland	3	8	31	68	0.5	7.4	18.7
blood vessel	10	129	117	234	2.1	32.7	68.9
bone element	1	7	4	6	0.2	1.4	3.1
brain	29	185	402	840	6.2	120.0	160.5
bronchus	2	9	18	36	0.4	3.1	9.7
esophagus	2	41	35	64	0.3	12.6	7.7
extraembryonic	11	66	193	412	3.0	46.5	89.9
eye	8	53	129	252	2.3	26.9	109.5
gonad	2	7	27	56	0.4	4.9	12.2
heart	8	69	169	342	2.0	38.8	76.0
kidney	8	29	84	174	2.0	19.5	96.5
large intestine	5	18	96	184	0.9	23.2	50.0
liver	3	8	26	62	0.5	4.9	19.8
lung	7	94	142	300	1.8	19.3	27.2
lymphatic vessel	2	30	21	286	0.4	3.6	11.9
lymphoblast	21	71	150	320	2.9	70.0	153.5
mammary gland	2	5	18	36	0.4	2.8	10.7
mouth	4	18	81	164	1.1	19.5	57.3
muscle organ	4	13	54	110	0.8	9.6	49.6
pancreas	2	13	38	84	0.5	8.1	30.9
prostate gland	2	8	23	50	0.3	4.2	78.1
skin	48	401	377	780	8.8	220.0	181.2
spinal cord	2	34	66	128	0.7	9.2	28.0
stomach	1	5	24	52	0.4	3.5	3.6
thyroid gland	3	24	63	136	0.7	13.6	27.0
tongue	2	8	51	106	0.7	13.7	26.1
urinary bladder	1	2	4	8	0.2	0.8	1.8
Total	193	1,355	2,443	5,291	40.8	739.7	1,409.4