Table 1. Significant associations of variants close to candidate genes with 1 kHz or 4 kHz auditory thresholds in the UK 1958 Birth Cohort.
The p-values above the significance threshold of p ≤ 6.76 × 10−4 are not shown, and 37 of the 38 candidate genes were tested; no human orthologue is known for Mir122, so this was not included.
| Lowest p-value within gene | Lowest p-value within 0.1 Mb of gene | |||||
|---|---|---|---|---|---|---|
| p-value | Trait | Variant | p-value | Trait | Variant | |
| AGAP1 | 0.000213 | 4 kHz | rs34690321 | |||
| 0.0000366 | 1 kHz | 2:236471205:TTTC_T | ||||
| BAI1 | 0.000304 | 4 kHz | rs34492225 | |||
| 0.000309 | 1 kHz | rs77210320 | ||||
| CDK14 | 0.0000818 | 4 kHz | rs185413613 | |||
| LRIG1 | 0.000628 | 1 kHz | rs140605629 | |||
| MCPH1 | 0.000277 | 4 kHz | rs2442589 | |||
| MKRN2 | 0.0000624 | 4 kHz | rs11718084 | |||
| 0.000309 | 1 kHz | rs9834598 | ||||
| PEX3 | 0.000186 | 4 kHz | rs161072 | 0.000166 | 4 kHz | rs223228 |
| PHF20 | 0.000309 | 1 kHz | rs187134453 | |||
| SETD5 | 0.000235 | 1 kHz | rs138835191 | |||
| 0.000516 | 4 kHz | rs2728943 | ||||
| SPNS2 | 0.000204 | 4 kHz | rs117002379 | |||
| TRAM2 | 0.000438 | 4 kHz | rs32073184 | 0.0000768 | 4 kHz | rs6458844 |