Table 1. Inhibitory Activity of the 4,5-Diarylisoxazole-3-carboxylic Acids and Selectivity over M. tuberculosis and Human Phosphatases^a.

^aScaffold of the new series of isoxazole-based compounds is shown at the top. Substitutions of the dichlorophenol head (red square) were explored during development of compound 5. Activities (IC₅₀ values in μM) toward M. tuberculosis MptpB, MptpA, and human PTP1B and Vaccinia H1-related (VHR) phosphatases are shown.