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. Author manuscript; available in PMC: 2019 Apr 11.
Published in final edited form as: Microbiol Spectr. 2019 Mar;7(2):10.1128/microbiolspec.BAI-0001-2019. doi: 10.1128/microbiolspec.BAI-0001-2019

Figure 3. Selective depletion of AM and IM results in a decrease or an increase in bacterial burden respectively.

Figure 3.

Treatment of mice by clodronate liposomes delivered either A. intranasally (i.n.) or B. intravenously (i.v.) to deplete the AM or the circulating monocytes, which depleted the recruited IM. Neither treatment impacted the neutrophil population within the infected lung tissue. Interestingly, depletion of AM lead to a reduction in bacterial burden, while depletion of IM lead to an increase in bacterial burden. The data demonstrate how modulation of the relative dimensions of the permissive (AM) and controller (IM) macrophage populations impacts directly on bacterial burden. Data taken from Huang et al. (44).