Table 3b:
HIV-stratified mortality risk by diagnosis of major depressive disorder (defined by ICD-9 code) in the Veterans Aging Cohort Study (VACS)
| Hazard ratio [95% CI] | |||
|---|---|---|---|
| HIV uninfected | HIV infected | ||
| Model 3 | No major depressive disorder | 1 (ref) | 1 (ref) |
| Major depressive disorder | 1.06 (1.02, 1.11) | 1.04 (0.99, 1.09) | |
| Model 4 | No major depressive disorder | 1 (ref) | 1 (ref) |
| Major depressive disorder | 0.98 (0.94, 1.02) | 0.99 (0.95, 1.04) | |
| Model 5 | No major depressive disorder | 1 (ref) | 1 (ref) |
| Major depressive disorder | 1.02 (0.98, 1.07) | 1.01 (0.96, 1.06) | |
| Model 6 | No major depressive disorder | 1 (ref) | 1 (ref) |
| Major depressive disorder | 1.01 (0.96, 1.05) | 0.97 (0.92, 1.02) | |
Model 3 adjusted age, sex, race, prevalent cardiovascular disease, chronic obstructive pulmonary disease, cancer, diabetes, systolic blood pressure, diastolic blood pressure, total cholesterol, estimated glomerular filtration rate, hemoglobin, and hepatitis C seropositivity. Model 4 adjusted for 3 for body mass index, smoking status, alcohol use, cocaine use. Model 5 adjusted Model 3 for baseline diagnosis of schizophrenia, bipolar disorder, and post-traumatic stress disorder. Model 6 adjusted Model 3 for baseline prescription of selective serotonin reuptake inhibitors and tricyclic antidepressant medications. All Models for the HIV-infected participants were then further adjusted for baseline use of antiretroviral therapy, CD4 cell count, and HIV-1 RNA level