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. Author manuscript; available in PMC: 2020 Apr 12.
Published in final edited form as: Circ Res. 2019 Apr 12;124(8):1214–1227. doi: 10.1161/CIRCRESAHA.118.314438

Figure 4: Fibroblast-specific Smad3 loss is associated with increased cardiomyocyte injury after 7 days of TAC.

Figure 4:

A-B: Hematoxylin-eosin staining demonstrated that many cardiomyocytes in pressure-overloaded FS3KO mice exhibited significant myofibrillar loss (myocytolysis, arrows). C: Quantitative analysis showed that FS3KO animals had a significantly higher myocytolysis index (*p<0.05, n=8–9). D-E: TUNEL staining was used to identify apoptotic cells in pressure overloaded hearts (arrows). Quantitative analysis showed that after 7 days of TAC, FS3KO mice had a significantly higher density of apoptotic cells (F), when compared with corresponding Smad3 fl/fl mice.