Table 3.

Significant predictors of clinical worsening during follow-up intervals in multivariate repeated measures logistic regression model

Positive Predictors of Clinical Worsening	OR (95% CI)	P Value
Female	1.27 (1.11–1.44)	0.0003
Age	1.04 (1.02–1.06)	<0.0001
Chronic migraine at visit A	1.57 (1.35–1.83)	<0.0001
History of status migrainosus	1.46 (1.26–1.69)	<0.0001
PedMIDAS/MIDAS grade at visit A
Grade 3 vs. 1	1.24 (1.03–1.48)	0.020
Grade 4 vs. 1	1.54 (1.29–1.84)	<0.0001
Nutraceutical intervention recommended at visit A	1.23 (1.10–1.37)	0.0002
Feeling depressed at consultation visit	1.31 (1.13–1.51)	0.0003
Negative Predictors of Clinical Worsening	OR (95% CI)	P Value
Visit B in the summer	0.65 (0.57–0.74)	<0.0001
Headache frequency at visit A	0.91 (0.90–0.92)	<0.0001
Pharmaceutical intervention recommended at visit A	0.78 (0.68–0.88)	0.0001
History of caffeine intake at visit A	0.87 (0.78–0.97)	0.010