Table 4.

Relationship between obesity trend from age 18 to 1995 (Time of cohort entry) and Risk of SLE among 55,951 women in the Black Women’s Health Study.

Obesity trend	Cases/person- years	Age and questionnaire period-adjusted HR (95%CI)*	Multivariable-adjusted HR (95%CI)**
Obese-obese	10/32,229	2.09 (1.08, 4.02)	2.03 (1.04, 3.95)
Obese-non obese	2/4,903	2.81 (0.69, 11.5)	2.81 (0.69, 11.5)
Non obese-obese	25/240,418	0.76 (0.49, 1.19)	0.78 (0.50, 1.22)
Non obese-non-obese	90/640,898	Reference	Reference

HR=hazard ratio; CI=confidence interval

^*Model 1: adjusted for age and period

^**Model 2: adjusted for age, period, age began alcohol intake (≤ 20 years), age began smoking (≤ 18 years), age began use of oral contraceptives (≤ 18 years of age), vigorous activity at age 21, age at menarche, and parental education.