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. 2019 Apr 11;9:5926. doi: 10.1038/s41598-019-42251-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Compound 4 toxicity requires iron and is inhibited by U0126. (A) NCI-H522 cells were exposed to the indicated concentrations of 4 in the presence or absence of deferoxamine. Bars = standard deviation. (B) Dose and time-dependency of compound 4 toxicity was tested on NCI-H522. (C) Inhibiting MEK1/2 reduced killing by 4 in HT1080 cells and NCI-H522. (D) Erk phosphorylation in NCI-H522 cells. Western blotting to detect phosphorylated Erk in the presence or absence of U0126 is shown. Actin is included as a loading control. To measure viability, cells were exposed to drugs for the times indicated and then stained with methylene blue.