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. 2019 Apr 11;9:5950. doi: 10.1038/s41598-019-42373-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hyperpolarized Nanodiamond Imaging. (a) Phantom schematic. One side of the “half-moon” phantom was filled with a mixture of hyperpolarized diamond and water (orange). The other half of the phantom is filled with water (blue). (b) Hyperpolarized 2 μm microdiamonds were imaged after dissolution in a 120 mg/mL water mixture, using the phantom described in a after 0 minutes and 30 minutes in the scanner. (c) Hyperpolarized 210 nm nanodiamonds in a teflon tube at 200 mg/mL concentration were imaged after transfer from the polarizer after 0 minutes and 5 minutes in the MRI scanner. (d) Images of hyperpolarized 2 μm microdiamonds in a teflon tube immediately after transfer from the polarizer at various concentrations (e) Co-registered ¹H:¹³C MRI of a mouse thorax following intrathoracic injection of hyperpolarized 2 μm diamond particles. The colorscale in all images indicates ¹³C signal magnitude in units of the noise floor. All scale bars are 3 mm in length.