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. 2019 Apr 11;9:5941. doi: 10.1038/s41598-019-42202-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of 1,5-AG by chromosome 17 variants. a,b With each additional copy of a significant chromosome 17 risk allele, median 1,5-AG values decrease indicating a dose-response effect. a 1,5-AG is winsorised at 1% and 99%. Legend: 0: no copies of rs61741107, rs148178887 or rs117355297 minor alleles. 1a: 1 copy of rs117355297 minor allele. 1b: 1 copy of rs61741107 or rs148178887 minor alleles. 2a: 2 copies of rs117355297 minor alleles. 2b: 1 copy of rs61741107 or rs148178887 + 1 copy of rs117355297 minor allele. 3: 1 copy of rs61741107 or rs148178887 + 2 copies of rs117355297 minor allele.