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. 2019 Apr 5;10:431. doi: 10.3389/fimmu.2019.00431

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Copyright © 2019 Tebruegge, Ritz, Donath, Dutta, Forbes, Clifford, Zufferey, De Rose, Robins-Browne, Hanekom, Graham, Connell and Curtis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proportions of mycobacteria-specific, cytokine-producing CD4+ T cells induced by antigenic stimulation in the three diagnostic groups. The different groups are indicated by the color: uninfected (white boxes), latent tuberculosis infection (orange boxes), active tuberculosis (red boxes). The respective antigenic stimulant is indicated on the left (note scales vary between stimulants), and the cytokines on the top of the figure. The boxes represent the medians; the whiskers indicate the IQR. All data shown are background-corrected. P-values were calculated with Mann-Whitney U-tests; all significant p-values are shown in the figure.