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. 2019 Apr 5;10:431. doi: 10.3389/fimmu.2019.00431

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Copyright © 2019 Tebruegge, Ritz, Donath, Dutta, Forbes, Clifford, Zufferey, De Rose, Robins-Browne, Hanekom, Graham, Connell and Curtis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proportions of mycobacteria-specific mono- and polyfunctional CD4+ T cells in the three diagnostic groups in (A) ESAT-6, (B) CFP-10, (C) PPD, and (D) MTBk stimulated samples. Box plot with Tukey whiskers; the boxes represent the interquartile range and the horizontal lines indicate the medians. The different groups are indicated by the color: uninfected (white boxes), latent tuberculosis infection (orange boxes), active tuberculosis (red boxes). All possible combinations of cytokine expression are shown on the x-axis (single cytokine producing CD4+ T cells toward the left; polyfunctional CD4+ T cells toward the right). All data shown are background-corrected. Statistically significant differences between the three diagnostic groups are indicated by star symbols: ^*p < 0.05; ^**p < 0.001; ^***p < 0.0001.