Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 11;10:1686. doi: 10.1038/s41467-019-09659-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 8 — STAG2 deficient cancer cells harbor increased sensitivity to cytotoxic chemotherapeutic agents and small molecule inhibitors of DNA double-strand break repair. a Summary of results from chemotherapeutic screen in four pairs of STAG2 isogenic human cells (H4 glioblastoma, 42MGBA glioblastoma, TC-106 Ewing sarcoma, and RPE hTERT shTP53). All four pairs showed similar sensitivities for all agents. b Survival plots of STAG2 isogenic H4 glioblastoma cells following treatment with etoposide (topoisomerase II inhibitor), rucaparib (PARP inhibitor), VX-970 (ATR inhibitor), and panobinostat (HDAC inhibitor). Each data point is the mean of 12 replicates from 3 independent experiments, and error bars show standard error of the mean. Source data are provided as a Source Data file