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. 2019 Apr 11;9:5925. doi: 10.1038/s41598-019-42392-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in the expression of six candidate miRNAs at three time points in the recurrence and nonrecurrence groups of patients with BTC after radical surgery. Four miRNAs were upregulated (A), and two miRNAs were downregulated (B). The grey line indicates the transition in the miRNA expression value of each patient. Red and blue lines show the transitions of median expression values of miRNAs in patients with BTC in the recurrence and nonrecurrence groups, respectively. ^apre, pre-operative time point. ^bpost, postoperative time point. ^crec, recurrence time point. ^dlast, last observation time point.