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. 2019 Apr 5;10:206. doi: 10.3389/fendo.2019.00206

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Copyright © 2019 Xia, Dufour and Giguère.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Current knowledge on the role of ERRα in liver physiology and pathology. Biological processes found either positively or negatively regulated by ERRα are shown. Under physiological conditions, ERRα can stimulate mitochondrial function and nutrient catabolism and repress de novo lipogenesis, gluconeogenesis and insulin signaling. Under pathological conditions, ERRα promotes the development of HFD-induced NAFLD on one hand and represses inflammation and protects from the development of rapamycin-induced NAFLD and liver cancer on the other.