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. 2019 Apr 5;10:650. doi: 10.3389/fimmu.2019.00650

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Copyright © 2019 Kotlan, Horvath, Eles, Plotar, Naszados, Czirbesz, Blank, Farkas, Toth, Tovari, Szekacs, Shoenfeld, Godeny, Kasler and Liszkay.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TreeView image to identify the aligned immunoglobulin variable gene regions highest similarity level. Cloned and randomly selected antibody variable region sequences in melanoma were subject to a detailed comparative DNA analysis by Clustal W, TreeView, and Vector NTI 11, in order to reveal DNA sequences with high homology to consensus. The levels of matches and mismatches in different parts of the aligned DNA sequences are indicated (A). TreeView image shows the representative results, where melanoma tissue originated antibody variable region gene inserted clones represented substantial similarities to the previously defined anti GD3 antibody variable heavy chain sequences (B).