Table 3.

Exploratory subgroup analysis of malaria episodes in cohort children stratified by age and receipt of ivermectin treatment

	Mean incidence per child*		Risk ratio (95% CI)	Risk difference (95% CI)
	Intervention group	Control group
All children not treated with ivermectin	2·19 (n=258)	2·54 (n=205)	0·86 (0·75 to 0·99)	−0·35 (−0·68 to −0·02)
Children aged ≤3 years and not treated with ivermectin	2·37 (n=191)	2·78 (n=165)	0·85 (0·74 to 0·97)	−0·42 (−0·76 to −0·07)
Children aged 4–5 years and not treated with ivermectin	1·69 (n=67)	1·53 (n=40)	1·11 (0·77 to 1·58)	0·16 (−0·40 to 0·72)
Children aged 4–5 years† and treated with ivermectin	1·29 (n=69)	2·29 (n=52)	0·56 (0·43 to 0·75)	−0·99 (−1·47 to −0·53)

^*Adjusted for the clustering effects of household and village.

^†121 (21%) of 590 cohort children were 4–5 years of age and were treated with ivermectin at some time during the trial; 69 children in the intervention group were treated with ivermectin repeatedly (four children four times, six children five times, and 59 children six times); and 52 children in the control group were treated with ivermectin once (six other children in the control group were treated once but were 3 years of age and therefore not included in this subgroup; and three children were ≥90 cm tall but were enrolled after the only mass drug administration in the control group). p values are not included because this was an exploratory analysis.