Table 2.

Univariable Cox proportional hazard regression models with Benjamini-Hochberg false discovery rate (FDR) adjustment

	Local recurrence		Regional recurrence		Distant recurrence			Overall survival
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	FDR	HR (95% CI)	P
Clinical factors
Age	0.99 (0.95-1.04)	.77	0.97 (0.93-1.01)	.12	0.99 (0.95-1.03)	.56	0.81	1.03 (0.99-1.06)	.10
T stage	0.55 (0.20-1.49)	.24	1.09 (0.66-1.78)	.74	0.78 (0.37-1.61)	.49	0.81	1.09 (0.63-1.90)	.75
Treatment factors
BED	1.00 (0.99-1.01)	.98	1.00 (0.99-1.01)	.89	1.00 (0.99-1.01)	.99	0.99	1.00 (0.99-1.01)	.51
GTV	0.99 (0.97-1.02)	.53	0.99 (0.97-1.01)	.35	0.98 (0.96-1.00)	.03	0.11	1.00 (0.98-1.01)	.51
Imaging metrics
SUVDx	1.04 (0.98-1.11)	.20	1.04 (0.99-1.09)	.15	1.02 (0.96-1.08)	.52	0.81	1.01 (0.97-1.06)	.61
SUVSim	1.04 (0.99-1.10)	.15	1.05 (1.00-1.10)	.06	1.01 (0.96-1.08)	.65	0.65	1.03 (0.99-1.08)	.12
MTVDx	0.99 (0.95-1.04)	.69	0.99 (0.95-1.02)	.43	0.95 (0.90-0.99)	.02	0.11	0.99 (0.97-1.02)	.62
MTVSim	0.99 (0.96-1.02)	.47	0.99 (0.97-1.01)	.27	0.97 (0.95-1.00)	.03	0.11	1.00 (0.99-1.01)	.61
SUVV	12.36 (0.38-404.55)	.16	4.34 (0.44-42.42)	.21	4.00 (0.38-42.57)	.25	0.63	11.8 (0.85-165.1)	.07
MTGR	0.63 (0.13-2.99)	.56	0.51 (0.14-1.93)	.32	0.78 (0.18-3.33)	.73	0.73	1.07 (0.29-3.94)	.91

Abbreviations: BED = biologically effective dose; CI = confidence interval; Dx = at diagnosis; GTV = gross tumor volume; HR = hazard ratio; MTGR = metabolic tumor growth rate; MTV = metabolic tumor volume; PET/CT = positron emission tomography with computed tomography; Sim = at simulation; SUV = standardized uptake value; SUVV = SUV velocity.

P-values less than 0.05 are bolded.