Fig. 5.

MRI and pathology at 4 h after injection of Ultrasmall superparamagnetic iron oxide (USPIO) without Annexin V for the mouse treated with anti-tumor drugs (Case 5). The tumor signal intensity (SI) on post-T₁-weighted MRI (T₁WI) (b) was similar to that on pre-T₁WI (a). The post/pre-SI ratio of the whole tumor on T₁WI was 1.17. The tumor signal on post T₂-weighted MRI (T₂WI) (d) was also similar to that on pre T₂WI (c). The post/pre-SI ratio of the whole tumor on T₂WI was 0.94. A round-shaped phantom (water) was also described at the side of the berry in (a–d). (e–g) represent hematoxylin-eosin, Perls DAB and TdT-mediated dUTP nick end labeling (TUNEL) staining, respectively. Perls DAB (%), TUNEL (%) and Necrosis (%) were 2.1, 1.0, and 28.1, respectively. The distribution of iron and apoptotic cells was quite different (arrows).