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ROI placement. On Arterial spin-labeling (ASL) control images, manual ROI were placed bilaterally in the white matter at the level of the centrum semiovale (two ROIs) (a), in the gray matter (GM) in the flow territory of the anterior (ACA), middle (MCA), and posterior cerebral artery (PCA) at the level of basal ganglia (six ROIs) (b), and in the GM at the level of the cerebellum (two ROIs) (c).
