Table 1.

Comparisons of EAE clinical characteristics and weights between diet groups.

Exp. #	Group	N	Incidence	Mortality	Day of onset mean± SD	Maximum clinical score median (25–75%)	Cumulative clinical score mean± SD	Weight Baseline (gr)	Weight Pre-immunization	Weight Post-immunization
1	IF	10	7/10	0/10	21.5 ± 3***	4 (0–4)	21.2 ± 17.6***	17.2 ± 0.8	16.5 ± 0.7**	14.9 ± 1.7**
	Ad libitum	10	10/10	0/10	12.6 ± 2.3	4 (3.75–4)	58.6 ± 13	16.8 ± 1.2	18.7 ± 1.2	17.7 ± 2.1
2	IF	10	4/10	0/10	14 ± 1.1	0 (0–3.62)	4.1 ± 6.2*	18.3 ± 1.6	19.6 ± 1.5	17.1 ± 2.2
	Ad libitum	10	8/10	0/10	11.3 ± 2.1	4 (2.25–4)	13.9 ± 9.9	18.2 ± 1.7	19.7 ± 1.5	19.3 ± 2.3
3	IF	10	2/10**	0/10	19.5 ± 2.1	0 (0–0.87)**	3.2 ± 6.9**	17.7 ± 1.1	18.1 ± 1.2*	19.6 ± 2.1
	Ad libitum	10	9/10	0/10	17.2 ± 4.5	4 (3–4)	22.5 ± 17	17.6 ± 0.9	19.6 ± 1	18.6 ± 2.6
4	IF	10	6/10	1/10	22 ± 3.2	3.5 (2–4)	2.1 ± 2.9*	18.2 ± 1.2	18 ± 1.3**	19.2 ± 2.4
	Ad libitum	10	10/10	1/10	19.3 ± 4.2	4 (3.75–4)	13.3 ± 11.4	19.4 ± 0.7	20.8 ± 1	18.5 ± 3.8

Incidence is reported as number of mice that developed EAE in each individual experiments (n=10/group in all experiments); mortality is reported as number of mice that died from EAE per group. Each individual experiment had a different duration; cumulative clinical scores were calculated for all mice over 30 days in Exp. #1, 17 days in Exp. #2, 24 days in Exp. #3 and 22 days in Exp. #4. Weights were measured after a day of fasting. Reported values are means ± SD.

^*P≤0.05;

^**P≤0.005;

^***P≤ 0.0005 by Mann-Whitney test or Fisher’s exact test (for incidence analyses).