Figure EV1. Bazedoxifene treatment suppresses proliferation and induces apoptosis of gastric tumor epithelium in gp130 ^Y757F mice.

• A
  Representative hematoxylin‐ and eosin‐stained cross sections through the glandular stomach of 20‐week‐old gp130 ^Y757F mice that were treated with either bazedoxifene (BZA) or vehicle control (VEH) for 7 consecutive weeks. Scale bars = 1 mm.
• B
  Representative immunohistochemistry staining for proliferative (Ki67 positive) and apoptotic (TUNEL positive) epithelium and those cells with high levels of the transcriptionally active pSTAT3 isoform (3+ intensity score) in sections of gastric tumors from mice as treated in (A). Immunohistochemical staining was quantified by Aperio analysis as outlined in the Materials and Methods section. Scale bars = 100 μm. Data are mean ± SEM, with n = 5 mice per cohort, P‐value derived from unpaired Student's t test.