Figure EV4. Acitretin increases ADAM10 transcription in murine and ADAM10 and sAPPa levels in aged rat neurons.

• A
  qPCRs for the ADAM10 and NrCAM mRNAs from wt neurons (DIV7) treated with acitretin (4 μM) or solvent for 48 h (preparation and treatment of the cells were performed like in Fig 4A). Two‐sided Student's t‐test (*P < 0.05, n = 15). Given are mean ± the standard error of the mean.
• B
  Cortical neurons were prepared from Wistar rat (embryonic day E18) and cultured for 21 days. Acitretin (2 μM) or solvent was added at DIV19. Two‐sided Student's t‐test (^n.s P > 0.05; *P < 0.05, n = 4). Given are mean ± the standard error of the mean. Representative Western blots are shown.

Source data are available online for this figure.