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. 2019 Mar 4;11(4):e9695. doi: 10.15252/emmm.201809695

Figure 7. TSPAN15 has opposite effects on ADAM10‐mediated NrCAM and APP shedding.

Figure 7

HEK293 cells were transiently transfected with hNrCAM, FLAG‐tagged hTSPAN15, either plasmids or the empty vector. Detection of sAPPα and sNrCAM in the conditioned media and ADAM10 in the cell lysate. Densitometric quantifications of the Western blots are shown (**P < 0.01; ***P < 0.001; ****P < 0.0001; two‐sided Student's t‐test was used for sNrCAM and mNrCAM and one‐way ANOVA with post hoc Dunnett's test for sAPPα and mADAM10, n = 6). Given are mean ± the standard error of the mean. The mean levels of solvent‐treated cells were set to 1. Representative Western blots are shown.Source data are available online for this figure.