Fig. 2.

a Hypothalamus (HYP), hippocampus (HIP), cortex (CTX), cerebellum (CER), skeletal muscle (SKM), and islet (ISL) expression of mCB1A, mCB1B, and mCB1a in wild-type and beta-cell CB1R-knockout mice (strain background: C57BL/6). One-way ANOVA (n = 4, the mean ± SEM, *P < 0.05). b Expression of mCB1A, mCB1B, and mCB1a in hypothalamus (HYP), hippocampus (HIP), cortex (CTX), and cerebellum (CER) of mice treated by vehicle or S961. c Expression of mCB1A, mCB2A and mCB2B isoform in liver of wild-type and β-CB1R^−/− knockout mice fed a standard (SD) or high-fat (HF) diet, and in liver of wild-type mice treated with vehicle or S961. Unpaired Student’s t-test between control and experimental groups (n = 4, the mean ± SEM, *P < 0.05). The y-axis is fold change of mCB1R isoforms in tissues of β-CB1-KO using the relevant wild-type mouse tissue as reference (a), vehicle vs S961 (b, c), and standard diet vs high-fat diet (c)