Table 1.
Components of the autophagy pathway that are essential for midgut degradation compared to starvation-induced autophagy in the fat body
| Drosophila Atg gene | Midgut degradation | Starvation in fat body | |
|---|---|---|---|
| Initiation | Atg1 | ✓ | ✓ |
| Atg13 | ✓ | ✓ | |
| Atg17 | ✓ | ✓ | |
| Atg101 | ✓ | ? | |
| Nucleation | Atg6 | ✗ | ✓ |
| Atg14 | ✗ | ✓ | |
| Vps15/ird1 | ✓ | ✓ | |
| Vps34/ Pi3K59F | ✓ | ✓ | |
| Conjugation systems | Atg3/Aut1 | ✗ | ✓ |
| Atg4a | ✗ | ✓ | |
| Atg4b | ? | ? | |
| Atg5 | ✗ | ✓ | |
| Atg7 | ✗ | ✓ | |
| Atg8a | ✓ | ✓ | |
| Atg8b | ? | ? | |
| Atg10 | ✓ | ? | |
| Atg12 | ✗ | ✓ | |
| Atg16 | ✗ | ✓ | |
| Atg9 trafficking system | Atg9 | ✓ | ✓ |
| Atg2 | ✓ | ✓ | |
| Atg18a | ✓ | ✓ | |
| Atg18b | ? | ? |
✓ Required; ✗ Not essential; ? Unknown