Table 1.
Association between NOP expression level and clinicopathologic variables in patients with NSCLC.
| Cases n (%) | NOP expression | ||||
|---|---|---|---|---|---|
| Low | High | P-value | X2 | ||
| AGE (YEARS) | |||||
| <60 | 50 (39) | 24 | 26 | 0.155 | 2.021 |
| ≥60 | 79 (61) | 48 | 31 | ||
| GENDER | |||||
| Male | 74 (57) | 42 | 32 | 0.802 | 0.063 |
| Female | 55 (43) | 30 | 25 | ||
| SMOKING STATUS | |||||
| Never smoke | 61 (47) | 33 | 28 | 0.710 | 0.138 |
| Smoke | 68 (53) | 39 | 29 | ||
| HISTOLOGICAL TYPE | |||||
| SCC | 41 (32) | 26 | 15 | 0.235 | 1.408 |
| ADC | 88 (68) | 46 | 42 | ||
| TNM STAGE | |||||
| I | 32 (25) | 24 | 8 | 0.014 | 10.679 |
| II | 29 (22) | 19 | 10 | ||
| III | 63 (49) | 27 | 36 | ||
| IV | 5 (4) | 2 | 3 | ||
| TUMOR SIZE | |||||
| ≤3 cm | 79 (61) | 49 | 30 | 0.074 | 3.189 |
| >3 cm | 50 (39) | 23 | 27 | ||
| LYMPHATIC INVASION | |||||
| Negative | 47 (36) | 32 | 15 | 0.034 | 4.515 |
| Positive | 82 (64) | 40 | 42 | ||
| SUVmax | |||||
| <9.5 | 66 (51) | 44 | 22 | 0.011 | 6.454 |
| ≥9.5 | 63 (49) | 28 | 35 | ||
| OPIOID REQUIREMENT | |||||
| OME<5 mg/day | 96 (74) | 58 | 38 | 0.073 | 3.224 |
| OME≥5 mg/day | 33 (26) | 14 | 19 | ||
NOP, nociceptin receptor; SCC, Squamous cell carcinoma; ADC, Adenocarcinoma; SUVmax, the maximum standardized uptake value; OME, oral morphine equivalents. Person chi-square test were used to analyze the data.