Table 2.
Univariate and multivariate analysis of clinicopathologic factors in NSCLC patients with respect to OS.
| Cases n (%) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|
| Survival time (months) | P-value | HR (95%CI) | P-value | ||
| AGE (YEARS) | |||||
| <60 | 50 (39) | 69.62 (4.40) | 0.549 | ||
| ≥60 | 79 (61) | 62.72 (3.49) | |||
| GENDER | |||||
| Male | 74 (57) | 63.43 (3.92) | 0.177 | ||
| Female | 55 (43) | 66.22 (3.62) | |||
| SMOKING STATUS | |||||
| Never smoke | 61 (47) | 68.13 (3.19) | 0.033 | 1.156 (0.723–3.179) | 0.271 |
| Smoke | 68 (53) | 60.71 (4.18) | |||
| HISTOLOGICAL TYPE | |||||
| SCC | 41 (32) | 58.64 (4.88) | 0.164 | ||
| ADC | 88 (68) | 69.57 (3.46) | |||
| TNM STAGE | |||||
| I-II | 61 (47) | 74.80 (3.47) | 0.003 | 1.292 (0.533–3.133) | 0.571 |
| III-IV | 68 (53) | 55.67 (3.81) | |||
| TUMOR SIZE | |||||
| ≤3 cm | 79 (61) | 74.40 (3.18) | <0.0001 | 1.569 (0.713–3.453) | 0.263 |
| >3 cm | 50 (39) | 49.54 (4.60) | |||
| LYMPHATIC INVASION | |||||
| Negative | 47 (36) | 74.54 (3.90) | 0.017 | 1.743 (0.698–4.351) | 0.234 |
| Positive | 82 (64) | 59.16 (3.68) | |||
| SUVmax | |||||
| <9.5 | 66 (51) | 71.14 (3.02) | <0.0001 | 2.790 (1.196–6.504) | 0.018 |
| ≥9.5 | 63 (49) | 50.55 (3.82) | |||
| NOP EXPRESSION | |||||
| Low | 72 (56) | 75.37 (3.33) | <0.0001 | 2.091 (1.035–4.227) | 0.040 |
| High | 57 (44) | 51.90 (4.05) | |||
| OPIOID REQUIREMENT | |||||
| OME<5 mg/day | 96 (74) | 73.24 (3.15) | 0.010 | 1.851 (0.732–4.744) | 0.209 |
| OME≥5 mg/day | 33 (26) | 57.25 (4.21) | |||
SCC, Squamous cell carcinoma; ADC, Adenocarcinoma; SUVmax, the maximum standardized uptake value; NOP, nociceptin receptor; OME, oral morphine equivalents. Overall Survival (OS) time were presented as mean (SEM) and were determined by the Kaplan-Meier method with log-rank test. Multivariable analysis of the independent factors was performed by the Cox proportional hazard model.